Why the study?
Does inhaled nitric oxide therapy and its acute withdrawal affect endogenous NOS activity and pulmonary vascular resistance in a lamb model?
Population
6 1-month-old lambs, mechanically ventilated and instrumented to measure vascular pressures and left…
Comparison
Inhaled nitric oxide for 6 hours, followed by… vs Pre-NO baseline values
Design
Preclinical
Follow-up
6 hours of NO exposure followed by 60 minutes…
Authors
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May underlie rebound PH after inhaled NO withdrawal in lambs; extends mechanistic insight but leaves open human relevance.
Does inhaled nitric oxide therapy and its acute withdrawal affect endogenous NOS activity and pulmonary vascular resistance in a lamb model?
Inhaled nitric oxide decreases endogenous NOS activity, providing a potential mechanism for the rebound pulmonary hypertension observed upon its acute withdrawal.
Black et al. (1999) studied this question.
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