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Editorial
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This editorial discusses the pharmacodynamic interaction between amlodipine and clopidogrel in the context of dual antiplatelet therapy for coronary stenting and acute coronary syndromes.
The current study by Li et al1 examines the pharmacodynamic interaction of amlodipine and clopidogrel. Dual antipla-telet therapy with aspirin and clopidogrel is standard of care for patients with cor-onary stenting and acute coronary syn-dromes, although newer, more potent P2Y12 inhibitors such as prasugrel and ticagrelor have recently become available. Clopidogrel is a prodrug that is metabo-lised in a two-step process by cytochrome P450 (CYP) and esterases to its principal metabolites (figure 1).2 Large interpatient variability has been observed in pharma-codynamic studies of clopidogrel response
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Kreutz et al. (2013) studied this question.
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