Why the study?
Does QRS prolongation ≥180 msec predict the development of life-threatening ventricular arrhythmias in patients with surgically repaired Tetralogy of Fallot?
Does QRS prolongation ≥180 msec predict the development of life-threatening ventricular arrhythmias in patients with surgically repaired Tetralogy of Fallot?
This review highlights that QRS prolongation ≥180 msec is a well-established, strong predictor of life-threatening ventricular arrhythmias in patients with surgically repaired Tetralogy of Fallot.
May refine VT risk stratification in repaired TOF; confirms association but leaves open prospective validation.
Tetralogy of Fallot (TOF) is a congenital heart disease frequently treated by surgical repair to relieve symptoms and improve survival. However, despite the performing of an optimal surgical repair, TOF patients are at times characterized by a poor long-term survival rate, likely due to cardiac causes such as ventricular arrhythmias, with subsequent sudden death. In the 80s it was irrefutably demonstrated that QRS prolongation ≥180 msec at basal electrocardiogram is a strong predictor for refining risk stratification for ventricular tachycardia in these patients. The aim of this research was to undertake a review of all studies conducted to assess the impact of QRS duration on the development of life-threatening ventricular arrhythmias in repaired TOF subjects.
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Bassareo et al. (2013) studied this question.