January 6, 2004Journal of Proteome Research

Proteome Analysis of Lipid Rafts in Jurkat Cells Characterizes a Raft Subset That Is Involved in NF-κB Activation

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Structured PICO

Population

Jurkat cells (human T lymphocyte cell line)

Intervention

CD3/CD28 costimulation and methyl-beta-cyclodextrin treatment

Comparator

Unstimulated/untreated cells

Outcome

Proteome composition of lipid rafts and NF-kappaB activationsurrogate

This study demonstrates that a specific subset of lipid rafts containing flotillin-1 is essential for CD3/CD28-induced NF-kappaB activation in T cells.

Discussion

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Implication

Potential T-cell immunomodulatory target; leaves open relevance to cardiovascular inflammation pending human validation.

Cite This Study

Tu et al. (2004) studied this question.

synapsesocial.com/papers/6a757bd306e84d3015dd73a7 https://doi.org/10.1021/pr0340779

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Proteome Analysis of Lipid Rafts in Jurkat Cells Characterizes a Raft Subset That Is Involved in NF-κB Activation

Structured PICO

Discussion

Implication

Cite This Study

Proteome Analysis of Lipid Rafts in Jurkat Cells Characterizes a Raft Subset That Is Involved in NF-κB Activation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider