June 21, 2014AJP Heart and Circulatory Physiology

PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

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Population

Wistar rat or guinea-pig isolated cardiomyocyte model

Comparison

Elevated extracellular glucose concentration and… vs Normal extracellular glucose concentration (5 mM)

Design

Preclinical

Authors

MSMark W. SimsUniversity of Leicester JWJames WinterAbbott (United Kingdom)SBSean BrennanUniversity of Liverpool

Discussion

Member takes

Implication

Acute hyperglycemia may blunt preconditioning via PKC in cardiomyocytes; leaves open whether inhibition improves outcomes in hyperglycemic MI.

Structured PICO

Population

Wistar rat or guinea-pig isolated cardiomyocyte model

Intervention

Elevated extracellular glucose concentration (20 mM) and inhibition of PKCα and β (using Gö6976 or specific inhibitor peptides)

Comparator

Normal extracellular glucose concentration (5 mM)

Outcome

Cardiomyocyte function and electrical stability (action potential duration, basal Ca2+, variability of Ca2+ transient amplitude, and response to ischemic preconditioning)surrogate

Elevated glucose exerts acute cardiotoxicity in isolated cardiomyocytes via PKCα and β, providing a mechanistic link between hyperglycemia and adverse outcomes post-myocardial infarction.

Cite This Study

Sims et al. (2014) studied this question.

synapsesocial.com/papers/6a757bd8375b1f3d8cdbec60 https://doi.org/10.1152/ajpheart.00894.2013

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Implication

Acute hyperglycemia may blunt preconditioning via PKC in cardiomyocytes; leaves open whether inhibition improves outcomes in hyperglycemic MI.

PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider