Predictive Values of the Blood CHG Index Combined with MHR or TG/HDL-C for Non-ST-Segment Elevation Acute Coronary Syndrome: A Cross-sectional Diagnostic Study

Q: What are the key findings of this study?

Combining the CHG index with MHR demonstrated a high predictive capacity for identifying high-risk coronary lesions in patients with non-ST-segment elevation acute coronary syndrome, achieving an AUC of 0.872.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) (n=226). Intervention: CHG index combined with MHR or TG/HDL-C vs. Individual markers (CHG index, MHR, TG/HDL-C). Primary outcome: High-risk coronary lesions (Gensini score ≥51) (AUC 0.872, 95% CI 0.815-0.929, p=<0.001).

Q: What does this research mean for the field?

Combining the CHG index with the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) demonstrates high predictive accuracy (AUC of 0.872) for identifying high-risk coronary lesions in patients with non-ST-segment elevation acute coronary syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the predictive capacity of the cholesterol, high-density lipoprotein, and glucose (CHG) index alone and in combination with MHR or TG/HDL-C for non-ST-segment elevation acute coronary syndrome.

Jing Yan; Rong Chen; Xia Li; Yilei Li; Jie Hu; Pengfei Li

doi:10.14218/erhm.2026.00005

July 29, 2026Exploratory Research and Hypothesis in MedicineOpen Access

Predictive Values of the Blood CHG Index Combined with MHR or TG/HDL-C for Non-ST-Segment Elevation Acute Coronary Syndrome: A Cross-sectional Diagnostic Study

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Key result

Combined CHG index and MHR predicts high-risk coronary lesions in NSTE-ACS with ~0.87 AUC.

AUC 0.872
95% CI 0.815-0.929
P<0.001
n=226

Why the study?

The study aimed to evaluate the predictive value of the CHG index alone and combined with MHR or TG/HDL-C for NSTE-ACS.

Does the combination of the CHG index with MHR or TG/HDL-C improve the prediction of high-risk coronary lesions in patients with NSTE-ACS?

Key Points

To evaluate the predictive capacity of the cholesterol, high-density lipoprotein, and glucose (CHG) index alone and in combination with MHR or TG/HDL-C for non-ST-segment elevation acute coronary syndrome.
Assessed laboratory biomarkers in patients with NSTE-ACS stratified by coronary lesion severity (low-risk group, n = 75; high-risk group, n = 75) and healthy controls.
Analyzed correlations with Gensini scores and performed univariate and multivariate binary logistic regression analyses to identify independent predictors.
Calculated receiver operating characteristic (ROC) curves to evaluate the predictive performance of individual indices and combined biomarker models.
The combination of CHG index and MHR achieved the highest predictive performance with an AUC of 0.872 (95% CI: 0.815-0.929, P < 0.001), while CHG index combined with TG/HDL-C yielded an AUC of 0.821 (95% CI: 0.755-0.887, P < 0.001).
Individually, MHR showed an AUC of 0.803 (95% CI: 0.730-0.876, P < 0.001), followed by TG/HDL-C with an AUC of 0.746 (95% CI: 0.666-0.826, P < 0.001), and CHG index with an AUC of 0.659 (95% CI: 0.573-0.746, P < 0.001).
Multivariate logistic regression demonstrated that CHG index (OR = 2.455, 95% CI: 1.040-5.791, P = 0.040), MHR (OR = 16.051, 95% CI: 13.677-99.650, P < 0.001), and TG/HDL-C (OR = 3.562, 95% CI: 1.868-6.793) independently predicted high-risk coronary lesions.

Study Design

Type

Cross-Sectional (n=226)

Multicenter

No

Structured PICO

Does the combination of the CHG index with MHR or TG/HDL-C improve the prediction of high-risk coronary lesions in patients with NSTE-ACS?

P

Population

150 patients with NSTE-ACS and 76 healthy controls were evaluated at a single center to assess the predictive value of the CHG index combined with MHR or TG/HDL-C for high-risk coronary lesions.

E

Exposure

Evaluation of blood biomarkers: cholesterol, high-density lipoprotein, and glucose index (CHG index) combined with monocyte-to-high-density lipoprotein cholesterol ratio (MHR) or triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C)

C

Comparator

Healthy controls (for NSTE-ACS diagnosis) and low-risk NSTE-ACS patients (for identifying high-risk coronary lesions)

O

Outcome

Predictive value (Area Under the Curve, AUC) for identifying high-risk coronary lesions (defined as Gensini score ≥51)surrogate

Main Result

Effect estimate: AUC 0.872 (95% CI 0.815-0.929)

p-value: p=<0.001

Limitations

Exclusion of patients with diabetes limits the generalizability of the findings to this substantial patient subgroup.
Exploratory, single-center study with a relatively modest sample size and potential for selection bias.
Residual confounding from unmeasured variables such as medication use, disease duration, and lifestyle factors cannot be ruled out.
Lack of external validation in independent multicenter cohorts.
No cross-validation or calibration analyses were performed, meaning the estimation of AUC may be overly optimistic.

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Implication

The combination of the CHG index with MHR or TG/HDL-C provides a high predictive value for identifying high-risk coronary lesions in patients with NSTE-ACS, offering a potential non-invasive tool for risk stratification.

Abstract

This study aimed to evaluate the predictive value of cholesterol, high-density lipoprotein, and glucose index (CHG index) alone and combined with the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) or triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) for NSTE-ACS.

Discussion

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Cite This Study

Yan et al. (2026) conducted a cross-sectional in Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) (n=226). CHG index combined with MHR or TG/HDL-C vs. Individual markers (CHG index, MHR, TG/HDL-C) was evaluated on High-risk coronary lesions (Gensini score ≥51) (AUC 0.872, 95% CI 0.815-0.929, p=<0.001). Combining the CHG index with MHR demonstrated a high predictive capacity for identifying high-risk coronary lesions in patients with non-ST-segment elevation acute coronary syndrome, achieving an AUC of 0.872.

synapsesocial.com/papers/6a757d2696d04a2f43f5a267 https://doi.org/10.14218/erhm.2026.00005

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Predictive Values of the Blood CHG Index Combined with MHR or TG/HDL-C for Non-ST-Segment Elevation Acute Coronary Syndrome: A Cross-sectional Diagnostic Study

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Predictive Values of the Blood CHG Index Combined with MHR or TG/HDL-C for Non-ST-Segment Elevation Acute Coronary Syndrome: A Cross-sectional Diagnostic Study

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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