Monocyte-to-HDL-cholesterol ratio and left atrial remodelling in atrial fibrillation: author's reply

We thank Dr Canpolat1 for his interest in our recent study.2 Many studies have established a strong association between inflammation, oxidative stress, and atrial fibrillation (AF); the pathogenesis and progression of AF seem to be simultaneously influenced by multiple factors.3–5 Canpolat et al. showed in their study that among commonly measured clinical factors, the ‘monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR)’—a combined inflammatory and oxidative stress marker—was independently associated with AF recurrence after cryo-energy ablation and correlated with the left atrial (LA) diameter.6 In our study, we investigated the role of intermediate CD14++CD16+ monocytes in the pathogenesis of AF and showed that a monocyte subgroup, intermediate CD14++CD16+ monocytes, …