Key result
Higher proportions of circulating intermediate CD14++CD16+ monocytes were independently associated with the presence of atrial fibrillation (OR 1.316; 95% CI 1.095-1.582; P=0.003).
Why the study?
Are circulating intermediate CD14++CD16+ monocytes increased in patients with atrial fibrillation compared to healthy controls?
Case-Control (n=60)
No
Are circulating intermediate CD14++CD16+ monocytes increased in patients with atrial fibrillation compared to healthy controls?
Odds Ratio: 1.316 (95% CI 1.095–1.582)
p-value: p=0.003
Intermediate CD14++CD16+ monocytes are significantly elevated in patients with atrial fibrillation and correlate with markers of left atrial functional remodeling.
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Elevated intermediate monocytes may mark AF-related inflammation; hypothesis-generating and requires prospective validation before clinical consideration.
Suzuki et al. (2016) conducted a case-control in Atrial fibrillation (n=60). Intermediate CD14++CD16+ monocytes vs. Healthy controls was evaluated on Presence of atrial fibrillation (OR 1.316, 95% CI 1.095-1.582, p=0.003). Higher proportions of circulating intermediate CD14++CD16+ monocytes were independently associated with the presence of atrial fibrillation (OR 1.316; 95% CI 1.095-1.582; P=0.003).
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