Why the study?
Are plasma endothelin-1 and CRP levels associated with pulmonary artery pressure in patients on hemodialysis for end-stage renal disease?
Are plasma endothelin-1 and CRP levels associated with pulmonary artery pressure in patients on hemodialysis for end-stage renal disease?
Plasma endothelin-1 and CRP levels are strongly correlated with pulmonary artery pressure in patients on hemodialysis, suggesting their potential utility as biomarkers for pulmonary arterial hypertension in this population.
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Supports endothelin-1 and CRP as candidate biomarkers for PAP in hemodialysis; hypothesis-generating and requires prospective validation.
Background: Chronic kidney disease, especially in patients with underlying pulmonary arterial hypertension (PAH), severely deteriorates the patients' quality of life. Early diagnosis would help to improve the outcome. Objectives: This study was performed to assess the association between the plasma level of endothelin-1 and the measured PAH in the patients on hemodialysis due to end-stage renal disease. Patients and Methods: In a descriptive, analytic, cross-sectional study, 40 patients were recruited. The pulmonary artery pressure (PAP) was measured via echocardiography and its association with plasma endothelin-1 as well as CRP levels was assessed. Results: There was a significant association between PAP and endothelin-1 (r = 0.93; P < 0.0001) as well as PAP and CRP (r = 0.893; P < 0.0001). Conclusions: The study demonstrated that in patients with underlying kidney disease, pulmonary artery pressure is strongly associated with endothelin-1 levels as well as CRP.
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Tavana et al. (2015) studied this question.
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