What question did this study set out to answer?

The aim is to measure plasma endothelin-1 levels in individuals with hypertension and chronic renal failure to explore its role in hypertension development.

May 1, 1990Hypertension

Plasma endothelin levels in hypertension and chronic renal failure.

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Why the study?

Are plasma endothelin-1 levels elevated in patients with hypertension and chronic renal failure compared to normotensive individuals?

Population

107 subjects including 32 with normal renal function, 24 patients with nondialyzed chronic renal failure…

Design

Cross-sectional

Authors

MSMasayoshi ShichiriKure Kyosai Hospital YHY HirataKasugai Municipal Hospital GAGiuseppe AndòInterventional Cardiology

Discussion

Member takes

Implication

Endothelin-1 elevation is associated with hypertension independent of renal status; hypothesis-generating for pathogenesis and therapeutic targeting.

Key Points

The aim is to measure plasma endothelin-1 levels in individuals with hypertension and chronic renal failure to explore its role in hypertension development.
Measured plasma levels of endothelin-1 using radioimmunoassay in 32 subjects with normal renal function and renal failure
Compared endothelin-1 levels among normal, hypertensive, and chronic renal failure groups
Analyzed differences between hyprtensive and normotensive subgroups in nondialyzed and hemodialyzed patients
Patients with essential hypertension had higher endothelin-1 levels (2.29 +/- 1.09 pg/ml) compared to normal subjects (1.41 +/- 0.50 pg/ml), p<0.025
Nondialyzed hypertensives (3.08 +/- 3.43 pg/ml) had higher levels than normotensives (0.73 +/- 0.34 pg/ml), p<0.05
Hemodialyzed hypertensives (2.66 +/- 1.92 pg/ml) had higher levels than normotensives (1.35 +/- 0.73 pg/ml), p<0.005

Structured PICO

Are plasma endothelin-1 levels elevated in patients with hypertension and chronic renal failure compared to normotensive individuals?

Population

107 subjects including 32 with normal renal function (21 normal subjects and 11 patients with essential hypertension), 24 patients with nondialyzed chronic renal failure, and 51 patients undergoing maintenance hemodialysis.

Outcome

Plasma immunoreactive endothelin-1 levelssurrogate

Circulating endothelin-1 levels are elevated in hypertensive patients regardless of renal function, suggesting a potential role in the pathogenesis or maintenance of hypertension.

Cite This Study

Shichiri et al. (1990) studied this question.

synapsesocial.com/papers/6a7618dff1e99ff85ab236df https://doi.org/10.1161/01.hyp.15.5.493

Topics

Hypertension management

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Implication

Endothelin-1 elevation is associated with hypertension independent of renal status; hypothesis-generating for pathogenesis and therapeutic targeting.

Plasma endothelin levels in hypertension and chronic renal failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Plasma endothelin levels in hypertension and chronic renal failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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