Key result
Plasma endothelin levels do not differ in hypertension but correlate positively with blood pressure.
Cross-Sectional
Reveals stable plasma endothelin concentrations across hypertension severities despite blood pressure correlations, suggesting essential hypertension does not stem from elevated endothelin production.
Plasma endothelin immunoreactivity was measured in normal controls, in mild essential hypertensive patients with no antihypertensive treatment, in moderate to severe hypertensives whose blood pressure was controlled by treatment, and in moderate to severe hypertensives whose blood pressure was not controlled by treatment. Endothelin immunoreactivity levels in plasma in the four groups were similar, but had a positive correlation with blood pressure in hypertensives although not in normotensives. The concentration in plasma of both C-terminal and N-terminal atrial natriuretic peptide also had a positive correlation with blood pressure in these hypertensive patients. We conclude that if plasma immunoreactive endothelin levels represent the result of endothelial production of endothelin, in absence of changes in catabolism of the peptide, essential hypertensive patients do not appear to have increased production of endothelin.
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Schiffrin et al. (1991) conducted a cross-sectional in Essential Hypertension. Essential hypertension vs. Normal controls was evaluated on Plasma endothelin immunoreactivity levels. Plasma endothelin immunoreactivity levels were similar between normal controls and patients with essential hypertension, but correlated positively with blood pressure in hypertensive patients.
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