Why the study?
Does nighttime blood pressure decline predict eGFR decline in patients with hypertension?
Does nighttime blood pressure decline predict eGFR decline in patients with hypertension?
Answers are grounded in this paper and cite their sources.
Nighttime blood pressure decline is a significant predictor of renal function preservation in hypertensive patients, with a 1% increase in SBP decline rate reducing the odds of eGFR decline by 46%.
< 0.001). In the fully adjusted model, the nighttime SBP, DBP, and mean BP were all related to a steeper rate of eGFR decline by -0.25 to -0.22 mL/min per 1% increase. The adjusted multivariable results indicated that the odds of an eGFR decline were reduced by 46% when the nighttime SBP decline rate increased by 1% (OR= 0.54, 95% CI: 0.46-0.62). The restricted cubic spline model indicated a non-linear dose-response relationship with the nighttime SBP, DBP, and mean BP. Nighttime BP may be an important biomarker of renal function injury in hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Cheng et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: