Double‐helical metal complexes, the helicates H 2 –H 5 , were found to bind to double‐helical DNA by spectroscopic, DNA‐melting, and electrophoretic‐mobility measurements. The helicates also inhibited the cleavage of DNA by two restriction enzymes, Sspl and EcoRV, a property which agrees with the binding occurring in the major groove of the double helix. Visible‐light irradiation of solutions containing a helicate and the pBR322 plasmid led to single‐strand cleavage, indicating that these complexes could be of interest as potential probes for nucleic‐acid structure.
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Schoentjes et al. (1995) studied this question.
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