May 25, 2007Circulation ResearchOpen Access

Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease

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Population

Animal models (mice, flies, worms, zebrafish) used to study integrin-linked kinase (ILK) functions

Design

Review

Authors

GHGregory E. HanniganOntario Institute for Cancer Research JCJohn G. ColesPediatric / Congenital Cardiology SDShoukat DedharPanacea Biotec (India)

Discussion

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Implication

ILK modulation should not yet inform clinical practice; extends preclinical cardiomyopathy models but leaves open human therapeutic validation.

Structured PICO

Population

Animal models (mice, flies, worms, zebrafish) used to study integrin-linked kinase (ILK) functions

Intervention

ILK gene knockout, inactivating mutations, or cardiac-specific transgenic expression

Outcome

Cardiac growth, contractility, repair, and survival

Integrin-linked kinase (ILK) is a crucial regulator of cardiac mechanotransduction, contractility, and repair, highlighting its potential importance in cardiomyopathies.

Cite This Study

Hannigan et al. (2007) studied this question.

synapsesocial.com/papers/6a75886ee42ca79ec1e7246e https://doi.org/10.1161/01.res.0000265233.40455.62

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Implication

ILK modulation should not yet inform clinical practice; extends preclinical cardiomyopathy models but leaves open human therapeutic validation.

Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider