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August 7, 2026Molecular Cancer Research

Integrative Transcriptional and Chromatin Analyses Reveal Enhancer-Mediated Regulatory Programs Driving Breast Cancer Metastasis

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Authors

FHFrances L. HerediaNMNatalia Maldonado-VazquezHFHomer Fogle

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Overview

Randomized trial uncovers regulatory mechanisms driving breast cancer metastasis, highlighting therapeutic targets.

Key Points

  • This research aims to define the regulatory mechanisms of breast cancer metastasis through a multi-omic approach.
  • Integrated transcriptomic (RNA-seq) and chromatin accessibility (ATAC-seq) profiling from primary tumors and matched metastases.
  • Conducted intra-patient comparisons of chromatin and gene expression profiles.
  • Identified enhancer-gene linkages associated with metastasis across liver and lung tissues.
  • Metastatic lesions showed increased chromatin accessibility and reprogramming of gene expression compared to primary tumors.
  • Thousands of enhancer-gene linkages were identified in metastatic samples, targeting clinically relevant genes.
  • Distinct transcription factor activity profiles were revealed in liver and lung metastases, independent of their expression levels.

Cite This Study

Heredia et al. (2026) studied this question.

synapsesocial.com/papers/6a758bc2847ab6d26c01f2d8https://doi.org/10.1158/1541-7786.mcr-26-0065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5955: Dissecting the enhancer logic in breast cancer metastasis through transcriptional, chromatin accessibility profiling and footprint-inferred transcription factor activity2026
  2. 2Defining the Regulatory Logic of Breast Cancer Using Single-Cell Epigenetic and Transcriptome Profiling2024 · 3 citations
  3. 3Abstract 2117: Single cell chromatin accessibility profiling of human metastatic tumor cells.2026
  4. 4Epigenetic Reprogramming in Cancer Metastasis: From Histone Modifications to Therapeutic Vulnerabilities2026
  5. 5Integrative transcriptomic analysis reveals novel targets for personalized medicine across seven metastatic breast cancer subtypes2026