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August 7, 2026Advanced ScienceOpen Access

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

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Authors

YJYiting JinShanghai Ocean UniversityZLZhimin LvPeople’s Hospital of RizhaoCBChao BianShenzhen University

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Implication

Randomized trial reveals the role of glutamate dehydrogenase in nitrogen metabolic adaptation in crustaceans, suggesting cellular mechanisms for alkaline stress response.

Key Points

  • This study aims to uncover the mechanisms crustaceans use to adapt to alkaline environments, focusing on nitrogen metabolism.
  • Characterization of Macrobrachium hainanense response to carbonate alkalinity stress using single-cell RNA sequencing.
  • Analysis of tissue damage, ammonia accumulation, and cell population responses under high alkaline conditions.
  • Evaluation of the impact of glutamate dehydrogenase inhibition on metabolic processes.
  • High alkalinity caused significant ammonia accumulation (specific levels not provided) and gill injury, leading to mitochondrial dysfunction and elevated oxidative stress.
  • Inhibition of glutamate dehydrogenase resulted in reduced alkaline tolerance and exacerbated tissue damage, implicating GDH in maintaining ATP levels.
  • GDH suppression altered nitrogen metabolism strategies by inhibiting urea metabolism and enhancing purine catabolism.

Cite This Study

Jin et al. (2026) studied this question.

synapsesocial.com/papers/6a758bc2847ab6d26c01f302https://doi.org/10.1002/advs.76978
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