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This study aims to explore the relationship between KLF2 and PCSK9 expression in RAW264.7 cells under oxidized LDL conditions.

August 7, 2026BiologyOpen Access

Regulation of PCSK9 During Oxidized LDL-Induced Foam Cell Formation in RAW264.7 Cells

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Exploratory study investigates PCSK9 regulation and modulation by KLF2 in foam cell formation, suggesting therapeutic potential.

This study aims to explore the relationship between KLF2 and PCSK9 expression in RAW264.7 cells under oxidized LDL conditions.
In vitro analysis using RAW264.7 cells treated with GGPP and GGTI298 to modulate KLF2 and PCSK9 expression.
Quantitative real-time PCR and immunocytochemistry utilized for gene expression assessment.
Molecular docking performed to assess the binding of GGTI298 to PCSK9.
Ox-LDL treatment significantly increased PCSK9 expression during foam cell formation.
GGPP treatment also significantly increased PCSK9 expression, whereas GGTI298 reduced it, suggesting GGTI298's negative regulation of PCSK9.
Docking studies indicated favorable binding of GGTI298 to PCSK9, suggesting a potential mechanism for its regulatory role.

Howlader et al. (2026) studied this question.

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