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The research aims to evaluate the effects of bortezomib and graphene oxide on glioblastoma cell viability and apoptosis.

August 7, 2026CellsOpen Access

Graphene Oxide Modulates ROS Production and Apoptotic Responses to Bortezomib in Human Glioblastoma Cells: An In Vitro Study

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The research aims to evaluate the effects of bortezomib and graphene oxide on glioblastoma cell viability and apoptosis.
Examined cell viability using MTT assay for bortezomib and graphene oxide treatments.
Assessed apoptotic markers through Western blot and caspase activity analyses.
Combined treatments to investigate interactions between bortezomib and graphene oxide.
Bortezomib and graphene oxide decreased cell viability in a dose-dependent fashion.
Combination treatment increased apoptosis with higher reactive oxygen species levels compared to bortezomib alone.
Downregulation of Bcl-2 and upregulation of NOXA and cleaved PARP indicated enhanced apoptotic signaling.

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In Vitro Study Shows Graphene Oxide Enhances Apoptosis Induction by Bortezomib in Glioblastoma Cells, Suggesting a New Treatment Strategy.

Krętowski et al. (2026) studied this question.

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In Vitro Study Shows Graphene Oxide Enhances Apoptosis Induction by Bortezomib in Glioblastoma Cells, Suggesting a New Treatment Strategy.