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August 7, 2026Autophagy ReportsOpen Access

Retinal ganglion cell autophagy: a housekeeper essential for neuronal homeostasis and survival

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Authors

YSYogapriya SundaresanUniversity of North TexasGZGulab S. ZodeUniversity of California, Irvine

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Implication

Randomized trial examines the role of autophagy in retinal ganglion cells, indicating its necessity for neuron health.

Key Points

  • This research investigates the role of autophagy in maintaining retinal ganglion cell health and preventing neurodegeneration.
  • Conditional deletion of Atg5 or Atg7 in retinal ganglion cells was performed to assess effects on autophagy and neuronal integrity.
  • Analysis of organelle morphology and cellular components was conducted following autophagy deficiency.
  • Autophagy deficiency resulted in progressive dysfunction in retinal ganglion cells and optic nerve degeneration.
  • Accumulation of damaged mitochondria and other organelles was observed, indicating impaired quality control.
  • Increased levels of p62 and LC3B were noted, highlighting disruptions in autophagic processes.

Cite This Study

Sundaresan et al. (2026) studied this question.

synapsesocial.com/papers/6a758c0f847ab6d26c01fc99https://doi.org/10.1080/27694127.2026.2710457
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deficient autophagy in retinal ganglion cells impairs the degradation of intracellular organelles, leading to neurodegeneration2026 · 1 citations
  2. 2Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models2023 · 36 citations
  3. 3Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice2011 · 218 citations
  4. 4Characterization of the role of autophagy in retinal ganglion cell survival over time using a rat model of chronic ocular hypertension2021 · 28 citations
  5. 5Mitochondrial dysfunction in glaucomatous degeneration2023 · 57 citations