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August 7, 2026Veterinary Medicine and ScienceOpen Access

Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy

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Authors

AÇAlper Yasin ÇİPLAKAtatürk UniversityBPBülent PolatUniversitätsklinikum Würzburg

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Implication

Randomized trial evaluates bupivacaine effects on pain and antioxidant activity in dogs undergoing laparoscopic ovariectomy, suggesting improved pain management.

Key Points

  • To evaluate the effects of topical bupivacaine on postoperative pain and biochemical markers in dogs undergoing laparoscopic ovariectomy.
  • Randomized, controlled trial with 24 healthy female dogs (ASA Class I).
  • Dogs received bupivacaine (2.2 mg/kg) or isotonic saline via topical application.
  • Postoperative pain was assessed at 0, 2, and 4 hours using the University of Melbourne Pain Scale.
  • UMPS scores were significantly lower in the bupivacaine group at all time points (p < 0.05).
  • Antioxidant enzyme activity (SOD and CAT) was higher in bupivacaine-treated dogs (p < 0.05).
  • No consistent differences were observed in systemic cytokine levels, with IL-6 lower in the bupivacaine group at 4 hours postoperatively.

Cite This Study

ÇİPLAK et al. (2026) studied this question.

synapsesocial.com/papers/6a758c2e847ab6d26c020090https://doi.org/10.1002/vms3.71144
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