Key result
PET/CT and biopsy identify primary pulmonary DLBCL from progressing ground glass opacities at 3 months.
Why the study?
This report highlights a unique cause of diffuse ground glass opacities to aid early recognition and prevent treatment delays.
Case Report (n=1)
Primary pulmonary diffuse large B-cell lymphoma can present uniquely as diffuse ground glass opacities on 18F-FDG PET/CT, highlighting the need for early recognition to prevent treatment delays.
Unique FDG PET/CT progression in primary pulmonary DLBCL suggests considering lymphoma in unresolved GGO; leaves open broader diagnostic validation.
We present unique fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) PET/CT findings of primary pulmonary diffuse large B-cell lymphoma (DLBCL). A 72-year-old man presented with two weeks of fever and mild upper respiratory symptoms. Initial CT and ¹⁸F-FDG PET/CT were unremarkable save for non-specific dependent ground glass opacities (GGO). His condition progressed with no unifying diagnosis, and repeat imaging three months later showed progression in the lungs. CT-guided lung core biopsy was performed. Histology showed primary pulmonary DLBCL. This case aims to highlight a unique cause of diffuse GGO, as early recognition is crucial to prevent delays in treatment.
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Chua et al. (2026) conducted a case report in Primary pulmonary diffuse large B-cell lymphoma (DLBCL) (n=1). 18F-FDG PET/CT was evaluated on Diagnosis of primary pulmonary DLBCL. A 72-year-old man with non-specific ground glass opacities on initial imaging was diagnosed with primary pulmonary diffuse large B-cell lymphoma after disease progression at 3 months.
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