Effects of a New Dihydropyridine Derivative, CV-4093-2HCI, on Renal Hemodynamics in Spotaneously Hypertensive Rats

The effects of a new calcium antagonist, CV-4093-2HCl, on renal hemodynamics were examined in anesthetized and conscious spontaneously hypertensive rats (SHR). In the anesthetized rats, CV-4093-2HCI (5 and 10 μg/kg. i.v.) showed a long-lasting hypotensive action, dilated renal vasculature, and increased renal blood flow. These renal hemodynamic actions of CV-4093-2HCI were more prominent than those of nicardipine (5 and 10 /μg/kg). Moreover. CV-4093-2HCI (10 /μg/kg. i.v.) inhibited renal vascular contractions induced by intravenous norepinephrine and angiotensin II. The inhibitory effect of CV-4093-2HCI was much more marked than that of nicardipine, although the inhibitory effects of both calcium antagonists on systemic pressor responses induced by the vasoactive substances were almost the same. In addition. CV-4093-2HCI (1 and 3 mg/kg, p.o) increased blood flow in the kidneys but not in the other organs except for the small intestine in conscious SHR. These results suggest that CV-4093-2HCI has a relatively higher affinity for the renal vascular bed (renal resistance vessels), and its effect on renal hemodynamics seems to be beneficial for treating hypertension.