Atropodiastereoselective CH Olefination of Biphenyl p‐Tolyl Sulfoxides with Acrylates

A stereoselective method for the synthesis of axially chiral biaryl scaffolds by CH bond functionalization was accomplished using chiral sulfoxide both as the directing group enabling the regioselective activation of a CH bond and as the chiral auxiliary generating an asymmetric environment in the coordination sphere of the metal complex. We have demonstrated the directing ability of the p ‐tolylsulfinyl group in promoting the Pd(II)‐catalyzed CH olefination of biphenyls. magnified image