Why the study?
Does combined hemodialysis and hemoperfusion effectively remove methotrexate and its metabolites in a patient with severe renal failure following high-dose methotrexate?
Population
1 patient with severe renal failure immediately after having been given high-dose methotrexate
Design
Case_report
Follow-up
24 days
Authors
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May support combined hemodialysis-hemoperfusion for methotrexate clearance in renal failure; leaves open confirmation in controlled studies.
Does combined hemodialysis and hemoperfusion effectively remove methotrexate and its metabolites in a patient with severe renal failure following high-dose methotrexate?
Combined hemodialysis and hemoperfusion, along with leucovorin and thymidine rescue, effectively removes methotrexate and prevents toxicity in severe renal failure following high-dose methotrexate.
Relling et al. (1988) studied this question.
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