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July 27, 2006DiabetesOpen Access

Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice

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Why the study?

Does liver-specific inhibition of ChREBP improve hepatic steatosis and insulin resistance in ob/ob mice?

Population

Leptin-deficient (ob/ob) mice

Design

Preclinical

Follow-up

7 days

Authors

RDRenaud DentinCentre National de la Recherche ScientifiqueFBFadila BenhamedCentre National de la Recherche ScientifiqueIHIsabelle HainaultInserm

Discussion

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Implication

Preclinical only; leaves open whether ChREBP inhibition benefits patients with steatosis or insulin resistance.

Structured PICO

Does liver-specific inhibition of ChREBP improve hepatic steatosis and insulin resistance in ob/ob mice?

P
Population
Leptin-deficient (ob/ob) mice
I
Intervention
Liver-specific inhibition of ChREBP using adenovirus-mediated RNA interference with short hairpin RNAs (shRNAs) for 7 days
O
Outcome
Hepatic steatosis and insulin resistancesurrogate

Liver-specific inhibition of ChREBP improves hepatic steatosis and restores insulin sensitivity in a mouse model of obesity, highlighting its role in metabolic regulation.

Cite This Study

Dentin et al. (2006) studied this question.

synapsesocial.com/papers/6a75900d1cd7cac2185ffd5chttps://doi.org/10.2337/db06-0200
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