Why the study?
Endothelial function and NO bioavailability determine aortic biomechanics, prompting evaluation of ex vivo aortic segment biomechanics using a new technique in mice with altered NO signaling.
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Population
Mouse models with altered NO signaling
Comparison
Different mouse models with altered NO signaling and different eNOS activity
Design
Ex vivo experimental study
Endothelial function and NO bioavailability are important determinants of aortic biomechanics and function. With a new technique we investigated the ex vivo aortic segment biomechanics of different mouse models with altered NO signaling. Our experiments clearly show that chronic distortion of NO signaling triggered several compensatory mechanisms that reflect the organism's attempt to maintain optimal central hemodynamics.
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Leloup et al. (2020) studied this question.
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