Key result
Mice overexpressing endothelial NO synthase had a 20% lower systemic vascular resistance than wild-type mice, an effect attenuated by blunted guanylyl cyclase responsiveness to NO.
Population
Isoflurane-anesthetized open-chest mice overexpressing human endothelial nitric oxide synthase…
Comparison
eNOS overexpression and pharmacological testing vs Wild-type (WT) mice
Design
Preclinical
Authors
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Hypothesis-generating for eNOS modulation in vascular disease; human studies required before clinical consideration.
In mice overexpressing eNOS, the expected massive vasodilation is attenuated by blunted guanylyl cyclase responsiveness to NO, rather than eNOS uncoupling or compensatory changes in other pathways.
Deel et al. (2007) studied Vasomotor control. eNOS overexpression vs. Wild-type mice was evaluated on Systemic vascular resistance (SVR). Mice overexpressing endothelial NO synthase had a 20% lower systemic vascular resistance than wild-type mice, an effect attenuated by blunted guanylyl cyclase responsiveness to NO.
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