Why the study?
Does fibronectin binding affect adherence and virulence in a rat model of Staphylococcus aureus infective endocarditis?
Does fibronectin binding affect adherence and virulence in a rat model of Staphylococcus aureus infective endocarditis?
Fibronectin binding is not solely responsible for Staphylococcus aureus adherence to damaged heart valves, suggesting a multifactorial adherence mechanism.
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Does not support fibronectin binding as sole driver in rat endocarditis; leaves open multifactorial adherence mechanisms for study.
The adherence characteristics in vivo and virulence of two isogenic strains of Staphylococcus aureus differing in fibronectin binding were compared in a rat model of catheter-induced infective endocarditis. No differences were found between the two strains. The results strongly point to the multifactorial nature of bacterial adherence to damaged heart valves and suggest that other binding functions can compensate for the lack of fibronectin binding in S. aureus.
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Flock et al. (1996) studied this question.
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