Why the study?
Does prophylactic high-dose oral N-acetylcysteine prevent postoperative atrial fibrillation in patients undergoing open heart surgery?
Population
240 patients undergoing open heart surgery, mean age approximately 60 years, 75% male.
Comparison
N-acetylcysteine 1,200 mg oral twice a day… vs Placebo starting 48 hours before and up to 72…
Design
RCT, randomized, double blind placebo-controlled
Follow-up
in-hospital
Authors
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High-dose oral NAC should not be used for POAF prophylaxis; this RCT confirms lack of benefit.
Does prophylactic high-dose oral N-acetylcysteine prevent postoperative atrial fibrillation in patients undergoing open heart surgery?
Prophylactic high-dose oral N-acetylcysteine does not significantly reduce the incidence of postoperative atrial fibrillation following open heart surgery.
Kazemi et al. (2013) studied this question.
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