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September 1, 1993Journal of Neurophysiology

Respiratory modulation of the activity in postganglionic neurons supplying skeletal muscle and skin of the rat hindlimb

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Population

Anesthetized rats, either breathing spontaneously or paralyzed and artificially ventilated

Comparison

Systemic hypercapnia, asphyxia, and bilateral… vs Baseline conditions (e.g., before vagotomy)

Design

Preclinical

Authors

HHHeinz‐Joachim HäblerHochschule Bonn-Rhein-SiegWJW. JänigHeidelberg UniversityMKM. KrummelMünchen Klinik

Discussion

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Implication

Sympathetic-respiratory coupling in rats is less differentiated than in cats; leaves open translation to human cardiovascular autonomic control.

Structured PICO

P
Population
Anesthetized rats, either breathing spontaneously or paralyzed and artificially ventilated
I
Intervention
Systemic hypercapnia, asphyxia, and bilateral vagotomy
C
Comparator
Baseline conditions (e.g., before vagotomy)
O
Outcome
Respiratory modulation of activity in postganglionic neurons of the lumbar sympathetic outflow to skeletal muscle and hairy skin of the hindlimbsurrogate

In rats, respiratory modulation of sympathetic activity to skeletal muscle and skin is less differentiated than in cats, primarily showing depression during inspiration and a peak during expiration.

Cite This Study

Häbler et al. (1993) studied this question.

synapsesocial.com/papers/6a7591e3756843cacbb21638https://doi.org/10.1152/jn.1993.70.3.920
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central respiratory modulation of medullary sympathoexcitatory neurons in rat1989 · 176 citations
  2. 2Respiratory Influence on the Vasomotor Center1957 · 54 citations
  3. 3Respiratory‐related activity patterns in preganglionic neurones projecting into the cat cervical sympathetic trunk.1992 · 37 citations
  4. 4Respiratory modulation of the activity in sympathetic neurones supplying muscle, skin and pelvic organs in the cat.1992 · 55 citations
  5. 5Respiratory‐related discharge pattern of sympathetic nerve activity in the spontaneously hypertensive rat.1990 · 76 citations