Strict protein-sparing modified fasting carries a risk of sudden death and severe arrhythmias even with close medical supervision.
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May signal arrhythmic risk with protein-sparing modified fasting even under supervision; hypothesis-generating case report that leaves causality and generalizability open.
Cardiovascular abnormalities developed in a patient during a protein-sparing modified fasting diet. Syncope was the complaint at the time of examination. Hypotension, persistent QTc interval prolongation, and a low QRS voltage were observed before the development of refractory ventricular tachycardia. At autopsy, antemortem thrombi were attached to the left ventricular endocardium and a fenestrated aortic valvule. Strick protein-sparing modified fasting is not without risk of sudden death even with close medical supervision.
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Jerry M. Brown (1978) studied this question.
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