Key result
Ten-hour fasting compared to 4-hour fasting in healthy volunteers reduced ECG wave amplitudes and durations, including a 3.87 ms reduction in QTcF and a 4.26 ms prolongation of the PR interval.
Why the study?
ECGs in fasting healthy volunteers are evaluated during early drug development trials for adverse cardiac effects, but the effect of fasting duration on ECG parameters is largely unknown.
Does 10-hour fasting compared to 4-hour fasting alter electrocardiographic parameters in healthy subjects?
Observational (n=432)
Does 10-hour fasting compared to 4-hour fasting alter electrocardiographic parameters in healthy subjects?
Extended fasting (10 hours vs 4 hours) significantly alters baseline ECG parameters, including reducing wave amplitudes and prolonging isoelectric intervals, which should be accounted for in early drug development trials.
Answers are grounded in this paper and cite their sources.
Fasting duration was associated with ECG changes in healthy volunteers; hypothesis-generating for protocol standardization in early drug trials.
INTRODUCTION: During early drug development trials, electrocardiograms (ECGs) in healthy volunteers who are in a fasting state are evaluated to screen for possible adverse cardiac effects. However, the effect of the duration of fasting on electrocardiographic parameters is largely unknown. We compared the effects of fasting on standard 12-lead electrocardiographic recordings. METHODS: Electrocardiograms were available for 432 healthy subjects (mean age 28.5 ± 12.5; 88.9% male) who participated in early drug development studies after 4- and 10-hr fasting. All ECGs were automatically analyzed for conduction intervals and wave amplitudes with the Marquette 12SL algorithm and compared among fasting duration. Mixed model analyses were used to identify confounding variables. RESULTS: After 10 hr of fasting, compared to after 4 hr of fasting, mean P-wave duration and amplitude were reduced by 1.95 ± 1.48 ms and 2.18 ± 2.75 μV, mean R wave and S wave amplitude were decreased by 25.83 ± 31.16 μV and 55.39 ± 78.72 μV, mean QRS duration was decreased by 1.84 ± 6.61 ms, and mean T-wave duration and amplitude were decreased by 2.06 ± 0.72 ms and 9.36 ± 17.21 μV (lead II). The mean PR interval was prolonged by 4.26 ± 17.67 ms, the ventricular rate was reduced by 3.64 ± 8.61 min, and QTcF was reduced by 3.87 ± 14.50 ms. These observations persisted after correction for demographics, electrolytes, blood pressure, heart rate variability, and diurnal variation. CONCLUSION: The present analysis showed that 10-hr fasting compared to 4-hr fasting resulted in changes to the surface ECG, consisting of a reduced wave amplitude and duration and increased isoelectric interval duration.
No takes yet. Share an insight, caveat, or question.
Stuijt et al. (2019) conducted an observational in Healthy volunteers (n=432). 10-hour fasting vs. 4-hour fasting was evaluated on Changes in standard 12-lead electrocardiographic recordings (conduction intervals and wave amplitudes). Ten-hour fasting compared to 4-hour fasting in healthy volunteers reduced ECG wave amplitudes and durations, including a 3.87 ms reduction in QTcF and a 4.26 ms prolongation of the PR interval.
Synapse has enriched 10 related papers. Consider them for comparative context: