Why the study?
Does food intake shorten the QT interval compared to fasting in healthy subjects?
Population
55 healthy subjects
Comparison
Standard breakfast 30 to 10 minutes prior to… vs Fasted condition
Design
RCT, randomized to treatment and a sequence of fasted and fed baseline…
Follow-up
4 hours
Authors
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Carbohydrate-rich meals shorten QTcF; supports their use as a positive control to demonstrate assay sensitivity in thorough QT studies.
Does food intake shorten the QT interval compared to fasting in healthy subjects?
A carbohydrate-rich meal significantly shortens the QTc interval, suggesting food effects can be used to demonstrate assay sensitivity in thorough QT studies.
Täubel et al. (2011) studied this question.
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