Why the study?
Does moxifloxacin 400 mg increase the QTc interval in healthy subjects compared to placebo?
Population
20 healthy subjects
Comparison
Moxifloxacin 400 mg vs Placebo (two-period crossover design)
Design
RCT, randomized, placebo-controlled
Authors
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Confirms moxifloxacin 400 mg as reliable positive control for TQT studies; supports predose baselines as sufficient versus time-matched.
Does moxifloxacin 400 mg increase the QTc interval in healthy subjects compared to placebo?
Moxifloxacin 400 mg reliably increases the QTc interval, supporting its use as a positive control in thorough QT studies and demonstrating that predose baselines are sufficient compared to time-matched baselines.
Bloomfield et al. (2008) studied this question.
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