Why the study?
Does sotalol administration alter the time course of ECG biomarkers of ventricular repolarization in healthy subjects?
Population
38 healthy subjects, mean age 27.4 ± 8.0 years, 27 males
Comparison
d-l sotalol 160 mg on day 1 and 320 mg on day 2 vs Baseline conditions (day 0)
Design
Cohort
Follow-up
4 hours post-dose on days 1 and 2
Authors
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QT prolongation timing after sotalol may inform ECG monitoring windows in research; leaves open translation to patients.
Does sotalol administration alter the time course of ECG biomarkers of ventricular repolarization in healthy subjects?
Different ECG biomarkers of ventricular repolarization display distinct kinetics following sotalol administration, which should be considered in the design of repolarization studies.
Extramiana et al. (2010) studied this question.
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