Why the study?
Does practolol prevent syncopal attacks in a child with Jervell and Lange-Nielsen syndrome?
Does practolol prevent syncopal attacks in a child with Jervell and Lange-Nielsen syndrome?
Treatment with the beta-blocker practolol successfully prevented syncopal attacks over a 3-year period in a child with Jervell and Lange-Nielsen syndrome.
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Practolol may prevent syncope in Jervell and Lange-Nielsen syndrome; single case leaves benefit unconfirmed.
A case of the surdocardiac syndrome of Jervell and Lange-Nielsen, with prolonged QT interval in the electrocardiogram at birth, is described. The affected girl presented 3 1/2 years later with severe iron deficiency anaemia, despite apparently adequate nutrition. At the age of 4 1/2 years she had a sudden attack of unconsciousness. Treatment with the beta-adrenoceptor blocker practolol was started and 3 years after initiation of this treatment she has been free from syncopal attacks. The QT interval remains prolonged. Her brother also had severe iron deficiency anaemia and had several attacks of unconsciousness before he died suddenly at the age of 3 1/2 years.
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Langslet et al. (1975) studied this question.
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