Why the study?
Does propranolol prevent syncopal attacks in patients with surdo-cardiac syndrome?
Does propranolol prevent syncopal attacks in patients with surdo-cardiac syndrome?
Propranolol appears effective in preventing syncopal attacks in patients with surdo-cardiac syndrome, whereas artificial pacemaking may be contraindicated due to the risk of provoking ventricular fibrillation.
Answers are grounded in this paper and cite their sources.
May favor propranolol over pacing for syncope in surdo-cardiac syndrome; leaves open confirmation in prospective studies.
First recognized in 1957, the surdo-cardiac syndrome includes congenital deafness, prolonged QT interval, and a high incidence of syncope and sudden death. Haemodynamic studies in two patients were normal except for an abnormal wave during left ventricular diastole probably related to abnormal left ventricular relaxation. The syncopal attacks are based on cardiac arrhythmias: both ventricular fibrillation and asystole may occur. Abnormal adrenergic stimulation of the heart is probably responsible. Propranolol appears to be effective in preventing the syncopal attacks. Artificial pacemaking provoked ventricular fibrillation in one patient and seems contraindicated.
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Olley et al. (1970) studied this question.
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