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This case series describes the natural history and high mortality of the surdocardiac (long Q-T) syndrome in a single family, highlighting the risk of fatal syncope in early adulthood.
This paper describes a family of nine siblings of whom five suffer from the surdocardiac syndrome. All five are deaf-mute and have medical histories typical of the syndrome, with frequent syncopal attacks during the childhood, often caused by stress. Two of these five siblings have not suffered more than single attacks since puberty and are still alive. The other three had had continuous frequent attacks into adult years and died in connection with syncopes at 20, 27 and 37 years of age. The diagnosis, pathogenesis, treatment and genetics of the syndrome are discussed.
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Andersson et al. (1979) studied this question.
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