Why the study?
Does a high fat or high sucrose diet alter myogenic tone in mesenteric arteries of male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
High fat diet or high sucrose diet for 6 weeks vs Control (Chow) diet
Design
Preclinical
Follow-up
6 weeks
Authors
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Diet-induced myogenic impairment in rats warrants no clinical dietary changes; leaves open translation to human vascular dysfunction in metabolic disease.
Does a high fat or high sucrose diet alter myogenic tone in mesenteric arteries of male Sprague-Dawley rats?
High fat and high sucrose diets impair myogenic tone in rat mesenteric arteries due to changes in vascular smooth muscle calcium signaling.
Sweazea et al. (2012) studied this question.
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