Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 12, 2006The Journal of PhysiologyOpen Access

Ca2+–calmodulin‐dependent protein kinase expression and signalling in skeletal muscle during exercise

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does exercise alter CaMK expression and signalling in human skeletal muscle?

Population

18 healthy men (8 in the duration group, 10 in the intensity group)

Comparison

Exercise at varying durations and intensities vs Rest (baseline)

Design

Other

Follow-up

Up to 90 minutes of exercise and 30 minutes post-exercise

Authors

ARAdam J. RoseBKBente KiensERErik A. Richter

Discussion

Loading...

Member takes

Overview

Rapid CaMKII activation during exercise leaves clinical translation open; extends mechanistic understanding of intensity-dependent signaling in human muscle.

Structured PICO

Does exercise alter CaMK expression and signalling in human skeletal muscle?

P
Population
18 healthy men (8 in the duration group, 10 in the intensity group)
I
Intervention
Exercise at varying durations (up to 90 min at ~67% VO2peak) and intensities (3 consecutive 10 min bouts at 35%, 60%, and 85% VO2peak)
C
Comparator
Rest (baseline)
O
Outcome
CaMK expression, autonomous CaMKII activity, and phosphorylation of downstream targets (PLN at Thr17, SRF at Ser103) in skeletal musclesurrogate

CaMKII is the major multifunctional CaMK in human skeletal muscle, and its rapid, sustained activation is dependent on exercise duration and intensity.

Cite This Study

Rose et al. (2006) studied this question.

synapsesocial.com/papers/6a7597c2fbccc8f4fd160fechttps://doi.org/10.1113/jphysiol.2006.111757
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise Increases Ca<sup>2+</sup>–Calmodulin‐Dependent Protein Kinase II Activity in Human Skeletal Muscle2003 · 181 citations
  2. 2Effect of endurance exercise training on Ca<sup>2+</sup>–calmodulin‐dependent protein kinase II expression and signalling in skeletal muscle of humans2007 · 88 citations
  3. 3Regulation and function of Ca2+–calmodulin‐dependent protein kinase II of fast‐twitch rat skeletal muscle2007 · 38 citations
  4. 4CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle2014 · 28 citations
  5. 5Effect of exercise on protein kinase C activity and localization in human skeletal muscle2004 · 57 citations