This case report describes the rapid progression and autopsy findings of extraskeletal osteosarcoma presenting in the thigh with lung metastasis.
Rapid progression despite chemotherapy signals poor prognosis; leaves open optimal therapies for extraskeletal osteosarcoma.
We report a case of extraskeletal osteosarcoma (ESOS) and autopsy findings. A 35-year-old man presented with an ossified tumor in the right thigh and lung metastasis. The lung tumors continued to develop despite multiagent chemotherapy and caused death within 8 months. Autopsy revealed many secondary lesions in the lungs, especially in the left lung. Histopathologically, the primary tumor and one of the secondary tumors showed proliferation of spindle-shaped tumor cells focally forming lace-like osteoid material. Therefore, we made a definite diagnosis of ESOS.
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Nagano et al. (2009) studied this question.
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