Plasmid-Mediated Coresistance to Streptogramins and Vancomycin in Enterococcus faecium HM1032

Enterococcus faecium has emerged as a major cause of nosocomial infections. Correspondingly, this species has become increasingly resistant to a broad range of antimicrobial agents, including aminoglycosides, penicillins, and glycopeptides (4). Quinupristin-dalfopristin, an injectable streptogramin, is proposed as an alternative drug for severe infections caused by multiply resistant E. faecium and in many cases could represent the only therapy available (3).