January 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Central Role of the MAPK Pathway in Ang II–Mediated DNA Synthesis and Migration in Rat Vascular Smooth Muscle Cells

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Population

Rat vascular smooth muscle cells (VSMCs)

Comparison

MAPK signaling inhibition using PD 98059 or… vs Control ODN-transfected VSMCs or uninhibited Ang…

Design

Preclinical

Authors

XXXiao-Ping XiUniversity of California, Los Angeles KGKristof GrafJüdisches Krankenhaus Berlin SGStephan GoetzeOrthopädische Praxis

Discussion

Member takes

Implication

Supports MAPK inhibition to curb Ang II-driven VSMC growth; leaves open translation to human vascular disease.

Structured PICO

Population

Rat vascular smooth muscle cells (VSMCs)

Intervention

MAPK signaling inhibition using PD 98059 (30 micromol/L) or antisense oligodeoxynucleotides (ODNs) against ERK1 and ERK2 MAPKs, and AT1-receptor blocker irbesartan

Comparator

Control ODN-transfected VSMCs or uninhibited Ang II stimulation

Outcome

Ang II-induced DNA synthesis, migration, and c-fos inductionsurrogate

MAPK is a critical regulatory factor for Ang II-mediated migration and growth in vascular smooth muscle cells, with DNA synthesis showing stronger MAPK dependence than migration or c-fos induction.

Cite This Study

Xi et al. (1999) studied this question.

synapsesocial.com/papers/6a7599a6469a9f8aa31611ff https://doi.org/10.1161/01.atv.19.1.73

View Full Paper

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Central Role of the MAPK Pathway in Ang II–Mediated DNA Synthesis and Migration in Rat Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central Role of the MAPK Pathway in Ang II–Mediated DNA Synthesis and Migration in Rat Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider