Why the study?
Predisposing factors for the development of a pre-capillary component in pulmonary hypertension associated with left heart disease remain elusive.
This case suggests that genetic variants such as in BMPR2 may predispose patients with left heart disease to develop a pre-capillary component of pulmonary hypertension.
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Does not change PH-LHD management; single case leaves open whether BMPR2 variants predispose to combined pre- and post-capillary disease.
Predisposing factors for the development of a pre‐capillary component in pulmonary hypertension associated with left heart disease remain elusive. We report the case of a patient with persistent combined post‐capillary and pre‐capillary pulmonary hypertension after cardiac transplantation, in whom a rare BMPR2 variant was found.
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Chomette et al. (2021) studied this question.
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