What question did this study set out to answer?

To determine whether acute systemic inflammation alters endothelial and arterial function in older adults, and whether preceding moderate aerobic exercise provides vascular protection.

January 24, 2014Experimental PhysiologyOpen Access

Effect of acute moderate exercise on induced inflammation and arterial function in older adults

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Why the study?

Does acute moderate-intensity exercise prevent vascular dysfunction from induced systemic inflammation in healthy older adults?

Key Points

To determine whether acute systemic inflammation alters endothelial and arterial function in older adults, and whether preceding moderate aerobic exercise provides vascular protection.
Randomized trial with 59 healthy older adults aged 55–75 assigned to an exercise or control group.
Participants received both an influenza vaccine to induce acute inflammation and a sham saline injection in a counterbalanced crossover design.
Endothelial function via flow-mediated vasodilatation, wave reflection (AIx75), β-stiffness, and inflammatory markers were assessed at baseline, 24 hours, and 48 hours post-injection.
No significant differences in endothelial function or arterial stiffness were observed between the exercise and control groups after induced inflammation.
Inflammatory markers rose significantly at 24 and 48 hours following vaccination relative to sham injection.
Flow-mediated vasodilatation, augmentation index normalized for heart rate (AIx75), and β-stiffness did not change significantly after vaccination across groups.

Structured PICO

Does acute moderate-intensity exercise prevent vascular dysfunction from induced systemic inflammation in healthy older adults?

Population

59 healthy volunteers between 55 and 75 years of age

Intervention

Acute moderate-intensity aerobic exercise immediately preceding induced systemic inflammation (influenza vaccination)

Comparator

Control group (no exercise) receiving the same induced inflammation (influenza vaccination) and sham (saline) injection in a counterbalanced crossover design

Outcome

Endothelial function (flow-mediated vasodilatation), wave reflection, and arterial stiffness at 24 and 48 hours after injectionssurrogate

Acute systemic inflammation induced by influenza vaccination does not impair endothelial function or increase arterial stiffness in healthy older adults, contrasting with known responses in younger individuals.

Discussion

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Implication

Acute inflammation does not impair endothelial function or arterial stiffness in healthy older adults; extends prior findings by showing age-specific vascular resilience.

Cite This Study

Ranadive et al. (2014) studied this question.

synapsesocial.com/papers/6a759a01a9c9d855ac67a6eb https://doi.org/10.1113/expphysiol.2013.077636

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Implication

Acute inflammation does not impair endothelial function or arterial stiffness in healthy older adults; extends prior findings by showing age-specific vascular resilience.

Effect of acute moderate exercise on induced inflammation and arterial function in older adults

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effect of acute moderate exercise on induced inflammation and arterial function in older adults

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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