Why the study?
Does cardiac-specific overexpression of HMGB1 improve cardiac function and survival after myocardial infarction in a mouse model?
Population
Transgenic mice with cardiac-specific overexpression of HMGB1 and wild-type littermate mice subjected to…
Comparison
Cardiac-specific overexpression of High-mobility… vs Wild-type littermate (Wt) mice
Design
Preclinical
Authors
Loading...
Hypothesis-generating for HMGB1 as post-MI target; leaves open translation to human therapy.
Does cardiac-specific overexpression of HMGB1 improve cardiac function and survival after myocardial infarction in a mouse model?
Cardiac-specific overexpression of HMGB1 enhances angiogenesis, restores cardiac function, and improves survival after myocardial infarction in mice, suggesting a potential therapeutic target for post-MI left ventricular dysfunction.
Kitahara et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: