Highlights a rare case of rheumatoid inflammation causing aortic valve perforation that required surgical replacement.
RA-associated aortic valve perforation may require replacement; leaves open prevalence and screening needs in rheumatoid patients.
An elderly woman with rheumatoid arthritis presented with progressive dyspnea. Transoesophageal echocardiography revealed severe aortic regurgitation with perforation of the non-coronary and left coronary leaflet. After stabilization and a week of antibiotic therapy, aortic valve replacement was performed. The valve histology showed palisading granulomas typical of rheumatoid etiology.
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Bachani et al. (2025) studied this question.
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