Why the study?
Elevated left atrial pressure at rest and during exercise is the primary cause of symptoms, hospitalization, and death in heart failure, warranting review of inter-atrial shunt devices to reduce left atrial pressure in HFmrEF and HFpEF.
Does an inter-atrial shunt device improve outcomes in patients with heart failure with mildly reduced and preserved ejection fraction?
Does an inter-atrial shunt device improve outcomes in patients with heart failure with mildly reduced and preserved ejection fraction?
This review summarizes the current evidence from pivotal trials on the use of inter-atrial shunt devices for patients with heart failure with mildly reduced and preserved ejection fraction.
ZvýťenĂ tlaku v levĂŠ sĂni v klidu a zejmĂŠna pĹi zĂĄtÄĹži je hlavnĂ pĹĂÄinou symptomĹŻ a zvýťenĂŠho rizika hospitalizace a ĂşmrtĂ u pacientĹŻ se srdeÄnĂm selhĂĄnĂm. MechanistickĂ˝ pĹĂstup se zavedenĂm zaĹĂzenĂ s vytvoĹenĂm mezisĂĹovĂŠho zkratu (inter-atrial shunt device, IASD) s cĂlem snĂĹžit tlak v levĂŠ sĂni u pacientĹŻ s mĂrnÄ snĂĹženou a zachovanou ejekÄnĂ frakcĂ levĂŠ komory se ukĂĄzal bĂ˝t v pilotnĂ studii proveditelnĂ˝ a bezpeÄnĂ˝. V nerandomizovanĂŠ studii REDUCE LAP-HF a v randomizovanĂŠ studii REDUCE LAP-HF I bylo zavedenĂ IASD spojeno se zlepĹĄenĂm symptomĹŻ a hemodynamickĂ˝ch parametrĹŻ. Dopad zavedenĂ IASD na riziko kardiovaskulĂĄrnĂch pĹĂhod vÄetnÄ ĂşmrtĂ a rizika hospitalizace pro srdeÄnĂ selhĂĄnĂ byl cĂlem multicentrickĂŠ randomizovanĂŠ faleĹĄnou procedurou kontrolovanĂŠ studie REDUCE LAP-HF II. PĹehledovĂ˝ ÄlĂĄnek se zamÄĹuje na zdĹŻvodnÄnĂ metody a vĂ˝sledky zĂĄsadnĂch studiĂ s IASD.
No takes yet. Share an insight, caveat, or question.
Málek et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: