Key result
In an experimental rabbit model, ischemic blood cardioplegia resulted in better intra-ventricular developed pressure (93.64 mmHg) compared to ischemic crystalloid cardioplegia (77.78 mmHg, p<0.005).
Why the study?
Does continuous blood antegrade-retrograde cardioplegia improve ventricular function in an isolated rabbit heart model of ischemia compared to crystalloid cardioplegia?
Does continuous blood antegrade-retrograde cardioplegia improve ventricular function in an isolated rabbit heart model of ischemia compared to crystalloid cardioplegia?
In an isolated rabbit heart model, continuous blood cardioplegia provided superior myocardial protection and preserved ventricular function compared to crystalloid cardioplegia.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for blood cardioplegia; human trials required before any practice consideration.
PURPOSE: To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function. METHODS: Rabbits were divided into four groups: Control--C(n=10); ischemic crystalloid cardioplegia--IC(n=10); ischemic blood cardioplegia--IB(n=10); ischemic non cardioplegia--INC(n=10). After the ischemic protocol period the ventricular function was analyzed by the intra-ventricular balloon technique. RESULTS: the intra-ventricular developed pressure (IVDP) was: C(92.90 +/- 6.86mmHg); IC(77.78 +/- 6.15mmHg); IB(93.64 +/- 5.09mmHg); INC(39.46 +/- 8.91mmHg) p< 0.005. The first derivative of intra-ventricular pressure in its positive deflection was: C(1137.50 +/- 92.23mmHg/sec); IC(1130.62 +/- 43.78mmHg/sec); IB(1187.58 +/- 88.38mmHg/sec); INC(620.02 +/- 43.80mmHg/se) p<0.005. The first derivate pressure in its negative deflection was: C(770.00 +/- 73.41mmHg/sec); IC(610.03 +/- 47.43mmg/sec); IB(762.53 +/- 46.02mmHg/sec); INC(412.35 +/- 84.36mmHg/sec) p< 0,005. The stress-strain angular logarithmic coefficient was: C(0.108 +/- 0.02); IC(0.159 +/- 0.038); IB(0.114 +/- 0.016); INC(0.175 +/- 0.038) p< 0.05. CONCLUSION: The ischemic group protected by blood cardioplegia showed better ventricular function than ischemic group protected by crystalloid cardioplegia and the non protected group.
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Martins et al. (2007) studied Myocardial ischemia (n=40). Continuous, blood, antegrade-retrograde cardioplegia vs. Ischemic crystalloid cardioplegia and ischemic non-cardioplegia was evaluated on Intra-ventricular developed pressure (IVDP) (p=< 0.005). In an experimental rabbit model, ischemic blood cardioplegia resulted in better intra-ventricular developed pressure (93.64 mmHg) compared to ischemic crystalloid cardioplegia (77.78 mmHg, p<0.005).
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