Key result
β-blocker use in patients with idiopathic or connective tissue disease-associated PAH was associated with similar survival and time to clinical worsening compared to non-use.
Why the study?
Does beta-blocker use improve survival or time to clinical worsening in patients with idiopathic or connective tissue disease-associated PAH?
Does beta-blocker use improve survival or time to clinical worsening in patients with idiopathic or connective tissue disease-associated PAH?
Answers are grounded in this paper and cite their sources.
This editorial highlights that beta-blocker use in PAH does not appear to improve survival or clinical worsening and may negatively impact functional capacity, though third-generation beta-blockers warrant further discussion.
We read with great interest the article from Bandyopadhyay et al . [1] regarding the outcomes of β-blockers use in pulmonary arterial hypertension (PAH). This study adds another piece in the very controversial debate opposing pro- and anti-supporters of β-blockers use in PAH. In this study, patients had idiopathic PAH (IPAH) or connective tissue disease-associated PAH. PAH patients receiving β-blockers had a similar survival and time to clinical worsening events compared with patients not receiving them. Functional outcomes were similar, although β-blocker use was associated with a tendency towards shorter walking distance. Malenfant and Perros discuss the potential usefulness of third generation β-blockers in pulmonary hypertension <http://ow.ly/VKMFn>
No takes yet. Share an insight, caveat, or question.
Malenfant et al. (2016) conducted a letter in pulmonary arterial hypertension (PAH). β-blockers vs. patients not receiving β-blockers was evaluated on survival and time to clinical worsening events. β-blocker use in patients with idiopathic or connective tissue disease-associated PAH was associated with similar survival and time to clinical worsening compared to non-use.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: